Action in Gachi: Space Orgasm takes place in an unknown city of the future, in the scenery of science fiction. This is a time of great discoveries and breakthroughs achieved through various experiments. Including human experiments. The main character and his lovers - Michael and Justin - just fell into the hands of a corporation known for its love of illegal research on male bodies.
Michael manages to get out and escape, promising to save Justin from the obnoxious busty scientists, even at the cost of his own life. Michael sneaks into the science complex and goes to help his soulmate, along the way fighting with the guards and remembering how good they were together.